dextromethorphan

https://www.mdpi.com/1660-4601/17/17/6336/htm

https://pubmed.ncbi.nlm.nih.gov/32878128/

Open Access
Article

Dextromethorphan Attenuates Sensorineural Hearing Loss in an Animal Model and Population-Based Cohort Study

Int. J. Environ. Res. Public Health 2020, 17(17), 6336; https://doi.org/10.3390/ijerph17176336

Received: 31 July 2020 / Revised: 27 August 2020 / Accepted: 28 August 2020 / Published: 31 August 2020

COMMENT: This link was added manually from a PubMed search (September 9, 2020), it has not (yet?) been retrieved by the system. Add this potentially missed link to error logbook, investigate cause.

https://www.sciencedirect.com/science/article/pii/S0041008X19302066?via%3Dihub

https://www.ncbi.nlm.nih.gov/pubmed/31153898?dopt=Abstract

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Evaluation of brain SERT with 4-[18F]-ADAM/micro-PET and hearing protective effects of dextromethorphan in hearing loss rat model.

Toxicol Appl Pharmacol. 2019 May 30;:114604

Authors: Liu CT, Huang YS, Chen HC, Ma KH, Wang CH, Chiu CH, Shih JH, Kang HH, Shiue CY, Li IH

Abstract

This study investigated the protective effects of dextromethorphan (DXM) on noise-induced hearing loss (NIHL) in rats. This study aimed to improve the auditory threshold and to understand the protective effects of DXM against N-methyl-d-aspartate (NMDA)-induced neurite degeneration of serotonergic neurons. The animals were exposed to 8-kHz narrowband noise at a 118-dB sound pressure level for 3.5 h. The hearing thresholds were determined by measuring the auditory brainstem response to click stimuli. Serotonin transporter (SERT) expression was determined through micro-positron emission tomography (PET) using N,N-dimethyl-2-(2-amino-4-18F-fluorophenylthio)benzylamine (4-[18F]-ADAM). We also investigated the effects of DXM on NMDA-induced morphological changes in the primary cultures of rat serotonergic neurons. NIHL significantly improved after prophylactic treatment with DXM (p < .05). SERT density in DXM-treated rats was significantly higher than that in non-DXM-treated rats. Because prophylactic medication restored the NMDA-inhibited neurite length of serotonergic neurons and presented SERT density, DXM could be a potential agent in alleviating NIHL. PMID: 31153898 [PubMed - as supplied by publisher]