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extracellular vesicles

Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo

December 21, 2020

CATEGORY:
Research

SCREENSHOT:
Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo Screenshot

TITLE:
Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo

CONTENT:
Clin Transl Med. 2020 Dec;10(8):e262. doi: 10.1002/ctm2.262.

ABSTRACT

The lack of approved anti-inflammatory and neuroprotective therapies in otology has been acknowledged in the last decades and recent approaches are heralding a new era in the field. Extracellular vesicles (EVs) derived from human multipotent (mesenchymal) stromal cells (MSC) can be enriched in vesicular secretome fractions, which have been shown to exert effects (eg, neuroprotection and immunomodulation) of their parental cells. Hence, MSC-derived EVs may serve as novel drug candidates for several inner ear diseases. Here, we provide first evidence of a strong neuroprotective potential of human stromal cell-derived EVs on inner ear physiology. In vitro, MSC-EV preparations exerted immunomodulatory activity on T cells and microglial cells. Moreover, local application of MSC-EVs to the inner ear significantly attenuated hearing loss and protected auditory hair cells from noise-induced trauma in vivo. Thus, EVs derived from the vesicular secretome of human MSC may represent a next-generation biological drug that can exert protective therapeutic effects in a complex and nonregenerating organ like the inner ear.

PMID:33377658 | DOI:10.1002/ctm2.262

SOURCE:
Clinical and translational medicine

PUBLISHER:

PMID:
pubmed:33377658

ID:
0b58ea4968e09ff10f4e1238c494f316pubmed:33377658

DOI:
10.1002/ctm2.262

DATE – PUBLISHED:
Wed, 30 Dec 2020 06:00:00 -0500

DATE – DOI:
2020-12-22T14:56:50Z

DATE – ADDED:
12/30/20 05:51PM

LINK – PUBMED:
https://pubmed.ncbi.nlm.nih.gov/33377658/

LINK – DOI:
https://doi.org/10.1002/ctm2.262

LINK – PUBLISHER:
https://onlinelibrary.wiley.com/doi/10.1002/ctm2.262

IMAGE:

REFERENCE:
Hearing Loss Treatment Report, Urgent Research, 2020-12-30T22:51:39+00:00, https://www.hearinglosstreatmentreport.com.

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