CATEGORY:
Research
SCREENSHOT:
TITLE:
Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo
CONTENT:
Clin Transl Med. 2020 Dec;10(8):e262. doi: 10.1002/ctm2.262.
ABSTRACT
The lack of approved anti-inflammatory and neuroprotective therapies in otology has been acknowledged in the last decades and recent approaches are heralding a new era in the field. Extracellular vesicles (EVs) derived from human multipotent (mesenchymal) stromal cells (MSC) can be enriched in vesicular secretome fractions, which have been shown to exert effects (eg, neuroprotection and immunomodulation) of their parental cells. Hence, MSC-derived EVs may serve as novel drug candidates for several inner ear diseases. Here, we provide first evidence of a strong neuroprotective potential of human stromal cell-derived EVs on inner ear physiology. In vitro, MSC-EV preparations exerted immunomodulatory activity on T cells and microglial cells. Moreover, local application of MSC-EVs to the inner ear significantly attenuated hearing loss and protected auditory hair cells from noise-induced trauma in vivo. Thus, EVs derived from the vesicular secretome of human MSC may represent a next-generation biological drug that can exert protective therapeutic effects in a complex and nonregenerating organ like the inner ear.
PMID:33377658 | DOI:10.1002/ctm2.262
SOURCE:
Clinical and translational medicine
PUBLISHER:
PMID:
pubmed:33377658
ID:
0b58ea4968e09ff10f4e1238c494f316pubmed:33377658
DOI:
10.1002/ctm2.262
DATE – PUBLISHED:
Wed, 30 Dec 2020 06:00:00 -0500
DATE – DOI:
2020-12-22T14:56:50Z
DATE – ADDED:
12/30/20 05:51PM
LINK – PUBMED:
https://pubmed.ncbi.nlm.nih.gov/33377658/
LINK – DOI:
https://doi.org/10.1002/ctm2.262
LINK – PUBLISHER:
https://onlinelibrary.wiley.com/doi/10.1002/ctm2.262
IMAGE:
REFERENCE:
Hearing Loss Treatment Report, Urgent Research, 2020-12-30T22:51:39+00:00, https://www.hearinglosstreatmentreport.com.
