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Glucose Protects Cochlear Hair Cells Against Oxidative Stress and Attenuates Noise-Induced Hearing Loss in Mice

January 7, 2021

CATEGORY:
Research

SCREENSHOT:
Glucose Protects Cochlear Hair Cells Against Oxidative Stress and Attenuates Noise-Induced Hearing Loss in Mice Screenshot

TITLE:
Glucose Protects Cochlear Hair Cells Against Oxidative Stress and Attenuates Noise-Induced Hearing Loss in Mice

CONTENT:
Neurosci Bull. 2021 Jan 7. doi: 10.1007/s12264-020-00624-1. Online ahead of print.

ABSTRACT

Oxidative stress is the key determinant in the pathogenesis of noise-induced hearing loss (NIHL). Given that cellular defense against oxidative stress is an energy-consuming process, the aim of the present study was to investigate whether increasing energy availability by glucose supplementation protects cochlear hair cells against oxidative stress and attenuates NIHL. Our results revealed that glucose supplementation reduced the noise-induced formation of reactive oxygen species (ROS) and consequently attenuated noise-induced loss of outer hair cells, inner hair cell synaptic ribbons, and NIHL in CBA/J mice. In cochlear explants, glucose supplementation increased the levels of ATP and NADPH, as well as attenuating H2 O2 -induced ROS production and cytotoxicity. Moreover, pharmacological inhibition of glucose transporter type 1 activity abolished the protective effects of glucose against oxidative stress in HEI-OC1 cells. These findings suggest that energy availability is crucial for oxidative stress resistance and glucose supplementation offers a simple and effective approach for the protection of cochlear hair cells against oxidative stress and NIHL.

PMID:33415566 | DOI:10.1007/s12264-020-00624-1

SOURCE:
Neuroscience bulletin

PUBLISHER:

PMID:
pubmed:33415566

ID:
0b58ea4968e09ff10f4e1238c494f316pubmed:33415566

DOI:
10.1007/s12264-020-00624-1

DATE – PUBLISHED:
Fri, 08 Jan 2021 06:00:00 -0500

DATE – DOI:
2021-01-07T18:43:13Z

DATE – ADDED:
01/08/21 01:01PM

LINK – PUBMED:
https://pubmed.ncbi.nlm.nih.gov/33415566/

LINK – DOI:
https://doi.org/10.1007/s12264-020-00624-1

LINK – PUBLISHER:
http://link.springer.com/10.1007/s12264-020-00624-1

IMAGE:

REFERENCE:
Hearing Loss Treatment Report, Urgent Research, 2021-01-08T18:01:22+00:00, https://www.hearinglosstreatmentreport.com.

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