Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration.
Development. 2019 09 02;146(17):
Authors: Roccio M, Edge ASB
The development of therapeutic interventions for hearing loss requires fundamental knowledge about the signaling pathways controlling tissue development as well as the establishment of human cell-based assays to validate therapeutic strategies ex vivo Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how they offer for the first time the opportunity to validate drug-based therapies, gene-targeting approaches and cell replacement strategies.
PMID: 31477580 [PubMed – indexed for MEDLINE]