PBM/NAC treatment may prevent hearing dysfunction caused by NIHL
CATEGORY:
Research
SCREENSHOT:
TITLE:
Combination photobiomodulation/N-acetyl-L-cysteine treatment appears to mitigate hair cell loss associated with noise-induced hearing loss in rats
CONTENT:
Lasers Med Sci. 2021 Apr 6. doi: 10.1007/s10103-021-03304-2. Online ahead of print.
ABSTRACT
Sensorineural hearing loss is an intractable disease. Acoustic overstimulation creates hearing loss; many patients exhibit social and emotional dysfunctions. In a model of noise-induced hearing loss (NIHL), low-level laser photobiomodulation (PBM) at a near-infrared wavelength significantly improved auditory brainstem response (ABR) thresholds. In addition, both N-acetyl-L-cysteine (NAC) and acetyl-L-carnitine (ALCAR) attenuated NIHL, reducing the effects of noise trauma in the cochlea and the central auditory system. Here, we combined PBM with antioxidants to explore hearing threshold recovery and morphological hair cell changes after rats were exposed to noise. The average auditory brainstem response thresholds after PBM/NAC combination treatment were reduced from the apex to the basal turn at all of 8, 16, and 32 kHz compared to the noise-only group. The PBM/NAC combination treated group exhibited intact outer hair cells in all turns, and significantly greater hair cell numbers in the middle and basal cochlear turns, than did controls. Thus, PBM/NAC treatment may prevent hearing dysfunction caused by NIHL.
PMID:33822307 | DOI:10.1007/s10103-021-03304-2
SOURCE:
Lasers in medical science
PUBLISHER:
PMID:
pubmed:33822307
ID:
0b58ea4968e09ff10f4e1238c494f316pubmed:33822307
DOI:
10.1007/s10103-021-03304-2
DATE – PUBLISHED:
Tue, 06 Apr 2021 06:00:00 -0400
DATE – DOI:
2021-04-06T07:04:00Z
DATE – ADDED:
04/06/21 07:30PM
LINK – PUBMED:
https://pubmed.ncbi.nlm.nih.gov/33822307/
LINK – DOI:
https://doi.org/10.1007/s10103-021-03304-2
LINK – PUBLISHER:
http://link.springer.com/10.1007/s10103-021-03304-2?utm_source=hearinglosstreatmentreport.com
IMAGE:
REFERENCE:
Hearing Loss Treatment Report, Urgent Research, 2021-04-06T23:30:28+00:00, https://www.hearinglosstreatmentreport.com.