photobiomodulation

PBM/NAC treatment may prevent hearing dysfunction caused by NIHL

CATEGORY:
Research

SCREENSHOT:
Combination photobiomodulation/N-acetyl-L-cysteine treatment appears to mitigate hair cell loss associated with noise-induced hearing loss in rats

TITLE:
Combination photobiomodulation/N-acetyl-L-cysteine treatment appears to mitigate hair cell loss associated with noise-induced hearing loss in rats

CONTENT:
Lasers Med Sci. 2021 Apr 6. doi: 10.1007/s10103-021-03304-2. Online ahead of print.

ABSTRACT

Sensorineural hearing loss is an intractable disease. Acoustic overstimulation creates hearing loss; many patients exhibit social and emotional dysfunctions. In a model of noise-induced hearing loss (NIHL), low-level laser photobiomodulation (PBM) at a near-infrared wavelength significantly improved auditory brainstem response (ABR) thresholds. In addition, both N-acetyl-L-cysteine (NAC) and acetyl-L-carnitine (ALCAR) attenuated NIHL, reducing the effects of noise trauma in the cochlea and the central auditory system. Here, we combined PBM with antioxidants to explore hearing threshold recovery and morphological hair cell changes after rats were exposed to noise. The average auditory brainstem response thresholds after PBM/NAC combination treatment were reduced from the apex to the basal turn at all of 8, 16, and 32 kHz compared to the noise-only group. The PBM/NAC combination treated group exhibited intact outer hair cells in all turns, and significantly greater hair cell numbers in the middle and basal cochlear turns, than did controls. Thus, PBM/NAC treatment may prevent hearing dysfunction caused by NIHL.

PMID:33822307 | DOI:10.1007/s10103-021-03304-2

SOURCE:
Lasers in medical science

PUBLISHER:

PMID:
pubmed:33822307

ID:
0b58ea4968e09ff10f4e1238c494f316pubmed:33822307

DOI:
10.1007/s10103-021-03304-2

DATE – PUBLISHED:
Tue, 06 Apr 2021 06:00:00 -0400

DATE – DOI:
2021-04-06T07:04:00Z

DATE – ADDED:
04/06/21 07:30PM

LINK – PUBMED:
https://pubmed.ncbi.nlm.nih.gov/33822307/

LINK – DOI:
https://doi.org/10.1007/s10103-021-03304-2

LINK – PUBLISHER:
http://link.springer.com/10.1007/s10103-021-03304-2?utm_source=hearinglosstreatmentreport.com

IMAGE:

REFERENCE:
Hearing Loss Treatment Report, Urgent Research, 2021-04-06T23:30:28+00:00, https://www.hearinglosstreatmentreport.com.

https://link.springer.com/article/10.1007%2Fs13534-019-00114-y

Applications of photobiomodulation in hearing research: from bench to clinic

Biomedical Engineering Letters

pp 1–8 | Cite as

Applications of photobiomodulation in hearing research: from bench to clinic

Authors
Jae-Hun LeeSehwan KimJae Yun JungMin Young LeeEmail author

Review Article
First Online: 18 June 2019

Abstract
Hearing loss is very common and economically burdensome. No accepted therapeutic modality for sensorineural hearing loss is yet available; most clinicians emphasize rehabilitation, placing hearing aids and cochlear implants. Photobiomodulation (PBM) employs light energy to enhance or modulate the activities of specific organs, and is a popular non-invasive therapy used to treat skin lesions and neurodegenerative disorders. Efforts to use PBM to improve hearing have been ongoing for several decades. Initial in vitro studies using cell lines and ex vivo culture techniques have now been supplanted by in vivo studies in animals; PBM protects the sensory epithelium and triggers neural regeneration. Many reports have used PBM to treat tinnitus. In this brief review, we introduce PBM applications in hearing research, helpful protocols, and relevant background literature.