This page tracks new and upcoming treatment options for sensorineural hearing loss (SNHL). What’s in development? What’s promising? What’s available soon? Current topics include NLRP3 inhibitors, AC102, FX-345, AUD1001, FX-322, OTO-413, PIPE-505, OTO-6XX, stem cells, SENS-401, AOK-1, ACOU085, gene therapy, CGF166, STR001, LY3056480, AP-001, and more.
Last updated: 8 months ago
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- Gene Therapy To Restore Hearing: A New Portal Jul 2, 2024
- New successful, expanded trial of groundbreaking therapy for genetic deafness suggests it may be available relatively soon Jun 5, 2024
- Delix Therapeutics Awarded Grant from the U.S. Department of Defense to Advance Neuroplastogen for Hearing Loss Jun 4, 2024
- Neuracle Science Initiates Phase 1/2 Clinical Trial of NS101 for the Treatment of Hearing Loss Mar 5, 2024
- Scientists discover biological mechanism of hearing loss caused by loud noise, and find a way to prevent it Feb 12, 2024
- AudioCure Pharma Awarded for Therapeutic Small Molecule for Hearing Loss Dec 7, 2023
- Harvard to evaluate whether two drugs approved by FDA can help regenerate the neural synapses lost between the auditory nerve and sensory cells and regenerate inner-ear synapses lost to noise exposure Jul 25, 2023
- Boston breakthroughs in gene and drug therapy routes to hearing loss solution Jun 15, 2023
- Drug-Like Molecules Regenerate Hair Cell-Like Cells in Adult Mice Apr 20, 2023
- Scientists Regenerate Hair Cells that Enable Hearing Apr 19, 2023
- Mogrify and Astellas announce collaboration to conduct research on in vivo regenerative medicine approaches to address sensorineural hearing loss Jul 5, 2022
- Autigen Announces Collaboration with Boehringer Ingelheim to Discover and Develop Novel Treatments for Hearing Loss Apr 13, 2022
- Phase 1b study of FX-345, new hearing loss drug candidate from Frequency Therapeutics, planned for second half of 2022 Jan 15, 2022
- Gene Therapy for Hearing Loss on the Horizon Dec 17, 2021
- Frequency Therapeutics Highlights Clinical Advancement of FX-322 and Unveils FX-345, a New Potential Restorative Treatment for Hearing Loss Nov 9, 2021
- Frequency Therapeutics Announces First Subject Dosed in FX-322 Phase 2b Acquired Sensorineural Hearing Loss (SNHL) Study Oct 21, 2021
- Eli Lilly-Backed Audion Therapeutics Initiates Phase 2 Clinical Trial of AUD1001 (LY3056480) in Patients with Sensorineural Hearing Loss Oct 1, 2021
- The Hunt for Drugs That Promote Ear Hair Cell Regeneration: Nanjing University researchers use cochlear organoids to identify drugs that can promote the regeneration of hair cells Sep 14, 2021
- USC Stem Cell scientists explore the latent regenerative potential of the inner ear Jul 30, 2021
- Researchers at University of Maryland School of Medicine (UMSOM) launch new online tool to advance medical discoveries to reverse progressive hearing loss Jul 19, 2021
- Pipeline Therapeutics Completes Phase 2a Study of PIPE-505 for Sensorineural Hearing Loss Jun 24, 2021
- KCNQ4 Activators as a Potential Treatment for Hearing Loss Jun 4, 2021
- CMS121, a fatty acid synthase inhibitor, reduced hearing loss and increased preservation of ribbon synapses in the mid-range frequencies May 31, 2021
- Vinpocetine Improves Hearing in Patients with Sensorineural Hearing Loss: Results from a Phase 2 Study May 16, 2021
- Frequency Therapeutics Expects to Initiate a New FX-322 Phase 2 Study Before End of 2021 May 13, 2021
- Start of ACOU085 (Acousia Therapeutics) phase 1 study in patients with hearing loss is planned for the second half of 2021 May 10, 2021
- Discovery of new hearing loss gene in humans [GAS2] May 7, 2021
- FGF signaling system for hearing restoration May 4, 2021
- UC-Irvine researchers studying nicotine-like drugs to improve hearing and restore auditory function May 1, 2021
- DB-301: Update on Decibel Therapeutics’ cochlear hair cell regeneration program for hearing loss Apr 28, 2021
- AOK-1 for hearing loss: a new regenerative drug from Hough Ear Institute Apr 22, 2021
- Rinri Therapeutics Raises £10 million to Advance its Novel Stem Cell Therapy to Reverse Sensorineural Hearing Loss Apr 20, 2021
- Department of Defense Hearing Restoration Research Program – Anticipated Funding Opportunities for Fiscal Year 2021 (FY21) Apr 19, 2021
- NLRP3 inhibitors such as Oridonin may provide new treatment strategy for noise-induced hearing loss Apr 5, 2021
- Estimated PIPE-505 Phase 2a Study Completion Date: June 12, 2021 Apr 2, 2021
- BREAKING: CGF166 Clinical Trial Results Posted Online… Apr 1, 2021
- HLAA to Hold Patient-Focused Drug Development Webinar for People and Families Living with Sensorineural Hearing Loss (April 8) Mar 26, 2021
- Frequency Therapeutics Releases New Data from Two FX-322 Clinical Studies Mar 23, 2021
- VEGF-A165 restores vascular function to the inner ear and could potentially reverse common forms of hearing loss… Mar 11, 2021
- Research center at Creighton University awarded $10.8 million NIH grant to help researchers discover new drugs for hearing loss Mar 5, 2021
- Frequency Therapeutics Announces Publication of FX-322 Phase 1/2 Data Showing Hearing Improvements in Sensorineural Hearing Loss Patients Feb 22, 2021
- Sensorion Presents New Preclinical Data on SENS-401 at ARO 2021: significant treatment benefits in rats with severe hearing loss when initiated within 7 days of acoustic trauma Feb 19, 2021
- Decibel Therapeutics to Present at the 44th Annual ARO Conference [DB-OTO gene therapy] Feb 19, 2021
- OTO-413 Phase 1/2 trial expansion in hearing loss expected to start in Q2 2021 with results anticipated in mid-2022 Feb 11, 2021
- New pill [SPI-1005] that may help improve age-related hearing loss by protecting delicate hair cells in the inner ear Feb 8, 2021
- PREVIEW: “Preclinical/Clinical Translational Evidence for a Potential Hearing Restoration Therapeutic, FX-322” [ARO 2021 Podium Presentation] Feb 7, 2021
- Decibel and Catalent Sign Development and Manufacturing Agreement for Dual-Vector Gene Therapy for the Treatment of Hearing Loss Feb 4, 2021
- PRESENTATION: “Perspective on the Potential of Restorative Therapeutics for Sensorineural Hearing Loss” [KOL event slides] Jan 23, 2021
- Frequency Therapeutics appoints Chief Manufacturing Officer as it prepares for larger studies in support of lead FX-322 program Jan 19, 2021
- Repurposed drug (dabrafenib) can treat hearing loss in humans Jan 7, 2021
- Sensorion Provides Update on Development of SENS-401 for Sudden Sensorineural Hearing Loss: Phase 2 topline results delayed, now expected in Q4 2021… Jan 5, 2021
- Frequency Therapeutics to Host Investor Event on the Potential for Restorative Treatments for Acquired Sensorineural Hearing Loss Dec 18, 2020
- Presentation: OTO-413 Phase 1/2 Top-Line Results [PDF] Dec 17, 2020
- Otonomy Reports Positive Top-Line Results from Phase 1/2 Clinical Trial of OTO-413 in Patients with Hearing Loss Dec 17, 2020
- Clinical Trial of FX-322 for Age-Related Hearing Loss Is Now ACTIVE Dec 17, 2020
- Sonova Invests €5 Million in Sensorion [SENS-401] as the Companies Plan a Collaboration in Hearing Loss Dec 15, 2020
- Upcoming Webinar from the Hearing Medicines Discovery Syndicate: “How and Why” to Commercialise your Hearing Research (Nov 26) Nov 23, 2020
- Promising targets for deafness drug discovery Nov 23, 2020
- Study of FX-322 in Patients with Severe SNHL to Start Before Year End Nov 16, 2020
- Frequency Therapeutics adds YET ANOTHER new FX-322 clinical trial… for SEVERE sensorineural hearing loss Nov 16, 2020
- Acousia Therapeutics: ACOU 085 phase 1 study in patients with hearing loss is “imminent”, according to press release Nov 2, 2020
- Decibel Therapeutics Announces Exclusive Licensing Agreements for Hearing Loss Gene Therapy Technology Nov 2, 2020
- Frequency Therapeutics Announces Expanded FX-322 Clinical Development Program and Upcoming Day-90 Phase 2a Analysis Oct 29, 2020
- SENS-401 Phase 2 trial results expected in mid-2021, prelinical data expected by end of 2020 Oct 21, 2020
- Estimated FX-322 Phase 2a Study Completion Date: May 21, 2021 Oct 8, 2020
- Atomic-level maps of fine ear filaments shine a light on hearing loss Oct 1, 2020
- How much will FX-322 cost? David Lucchino, Frequency Therapeutics CEO, talks pricing and value… Sep 24, 2020
- Decades-old theory on how ears work is wrong: After 30 years, scientists still don’t know how the ear tells the brain what it is hearing Sep 23, 2020
- Frequency Therapeutics Completes Enrollment of FX-322 Phase 2a Study for Sensorineural Hearing Loss Sep 22, 2020
- Frequency’s hearing loss treatment shows long-term promise Sep 14, 2020
- Frequency Therapeutics Presents Results Demonstrating Sustained Improvement in Hearing Loss Patients Treated with FX-322 Sep 13, 2020
- Role of protein in development of new hearing hair cells: Finding could lead to future treatments for hearing loss Sep 11, 2020
- Decibel Therapeutics to Present at Citi’s 15th Annual BioPharma Virtual Conference on September 8, 2020 Sep 2, 2020
- Frequency Therapeutics Expects to Share FX-322 Phase 2a Study Results in Q2 2021 Aug 12, 2020
- PIPE-505 Clinical Trial Update: Pipeline adds 4 new study locations across the United States… Aug 6, 2020
- Otonomy Announces Exclusive License Agreement with Kyorin for Novel Compound in OTO-6XX Hearing Loss Program Aug 3, 2020
- Hough Ear Institute receives $300K grant to support research treatments for hearing loss Jul 27, 2020
- How Artificial Intelligence Could Completely Restore Hearing: Lip-reading AI and Elon Musk’s “Neuralink” could deliver near-perfect audio and skip the ear entirely Jul 24, 2020
- Pipeline Therapeutics Initiates Phase 1/2a Clinical Trial of PIPE-505 in Sensorineural Hearing Loss – Topline results expected in early 2021… Jul 23, 2020
- UPDATE: Pipeline Therapeutics Begins Recruiting Patients for Phase 1/2a Study of PIPE-505 for SNHL Jul 21, 2020
- Dramatic Effect: Bone disease medications (bisphosphonates) may reverse sensorineural hearing loss Jul 17, 2020
- Researching a Medication to Treat Sensorineural Hearing Loss Jul 15, 2020
- Pipeline Therapeutics Initiates Phase 1/2 Clinical Trial of PIPE-505 for Sensorineural Hearing Loss Jul 8, 2020
- A simpler way to make sensory hearing cells Jul 1, 2020
- Otonomy Provides Update on OTO-413 Clinical Trial: Results from Phase 1/2 study of OTO-413 for hearing loss expected in fourth quarter of 2020 Jun 15, 2020
- Study charts developmental map of inner ear sound sensor in mice: Data offers valuable resource for developing stem cell-based therapies for hearing loss May 28, 2020
- Stem Cell Study Offers Clues On How To Potentially Restore Hearing May 26, 2020
- Frequency Therapeutics Shares Clinical Data From Exploratory Study Confirming Delivery of FX-322 to the Cochlea May 14, 2020
- Decibel Therapeutics, a clinical-stage biotechnology company developing novel gene therapeutics for restoration of hearing loss, to present at the 23rd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) May 11, 2020
- Akouos to Present Data from Inner Ear Gene Therapy Platform at 23rd ASGCT Annual Meeting May 11, 2020
- NO COVID-19 SLOWDOWN: Frequency Therapeutics Adds Another Recruitment Site for FX-322 Phase 2a Study Apr 14, 2020
- Strekin AG Completes Phase 3 Clinical Study of STR001 to Restore Hearing in Patients with SSNHL Mar 27, 2020
- COMPLETED: Novartis Phase 1/2 Trial of CGF166, an Inner Ear Gene Therapy for Hearing Loss Mar 19, 2020
- Coronavirus Delays Sensorion’s Hearing Loss Phase II Trial of SENS-401 Mar 16, 2020
- Sensorion provides update on Phase 2 study of SENS-401 (Arazasetron) to treat Sudden Sensorineural Hearing Loss (SSNHL) Mar 13, 2020
- Dozens of backers chime in on $100M round for hearing loss startup Mar 5, 2020
- Akouos Raises $105 Million in Funding to Advance First-In-Human Clinical Studies of AK-OTOF, a Potential Gene Therapy for Sensorineural Hearing Loss Mar 3, 2020
- Researchers in Oklahoma City developing hearing restoration pill (NHPN-1010) that regenerates nerve endings between the cochlea and auditory nerve Feb 28, 2020
- Discovery of a pharmacological treatment that could “wake up” the human body’s ability to naturally regenerate lost hair cells and reverse hearing loss Feb 24, 2020
- Oblato Biotech Company Acquires Hearing Loss Drug (NHPN-1010) Discovered by Hough Ear Institute Scientists Feb 11, 2020
- Researchers find proteins that might restore damaged sound-detecting cells in the ear Aug 5, 2019
- Investor dollars flow to Frequency Therapeutics as company prepares to advance lead clinical candidate, FX-322, into Phase 2a study of sensorineural hearing loss Jul 23, 2019
- Research Spotlight: Avenanthramide-C (AVN-C) prevents noise- and drug-induced hearing loss while protecting auditory hair cells from oxidative stress Jul 21, 2019
- Astellas picks up Frequency’s regenerative hearing loss med FX-322 outside U.S. for $80M Jul 17, 2019
- Astellas Adds To Regenerative Medicine Portfolio In Hearing Loss Deal With Frequency Therapeutics [Note: Paywall] Jul 17, 2019
- Sensorion Receives FDA IND Approval for Arazasetron (SENS-401) for the Treatment of Sudden Sensorineural Hearing Loss (SSNHL) Jul 12, 2019
- New research shows that different types of hearing loss are best treated by specially tailored solutions Jul 9, 2019
- Inner Ear Drug Delivery: Tomorrow’s Treatment for Hearing Loss? Jul 4, 2019
- Optimized gene-editing system halts hearing loss in mice with hereditary deafness Jul 3, 2019
- Radical cure for deafness may have been found thanks to lab animals: Scientists revealed that hearing has been salvaged in mice by ‘snipping’ a mutation out of their DNA Jul 3, 2019
- Sound Pharmaceuticals announces positive topline results from SPI-1005 Phase 2b clinical trial… clinically relevant improvements in sensorineural hearing loss… 65% and 95% over placebo at 8 weeks… Jun 25, 2019
- Daewoong to develop hearing loss treatment using ion-channel platform tech Jun 14, 2019
- Triamcinolone a Safe and Efficacious Treatment Option for Idiopathic Sudden Sensorineural Hearing Loss, Study Says Jun 14, 2019
- Drug to treat malaria could mitigate hereditary hearing loss Jun 11, 2019
- Sensorion Announces the Signature of a Partnership Framework Agreement with Institut Pasteur on Gene Therapy Programs Targeting Hearing Loss May 27, 2019
- Rinri Therapeutics Secures £1.4 Million Seed Funding to Advance Its Novel Regenerative Cell Therapy to Treat Sensorineural Hearing Loss May 20, 2019
- Novartis begins recruiting patients with hearing loss for Phase 2 (Part C) of inner ear gene therapy [CGF166] trial May 13, 2019
- Frequency’s FX-322 improves hearing function in trial subjects Apr 10, 2019
- Biotech Frequency shows early positive results for small-molecule hearing loss therapy Apr 9, 2019
- Drug being tested in London could be breakthrough in treating hearing loss Mar 6, 2019
- Local company working on treatment to reverse hearing loss Mar 1, 2019
- Scientists used gene therapy to cure deafness in mice Feb 20, 2019
- Audion Therapeutics and REGAIN Consortium Announce Positive Results from Phase I Study of Notch Inhibitor LY3056480 in Patients with Sensorineural Hearing Loss Feb 5, 2019
- AudioCure Pharma’s AC102 receives EMA orphan drug designation for the treatment of sudden sensorineural hearing loss (SSNHL) Jan 29, 2019
- Melbourne researchers flag potential for new hearing loss treatment using nanoparticles Nov 8, 2018
- Otonomy Presents Data Highlighting Potential of OTO-413, an Otic Sustained-Exposure Formulation of BDNF, to Treat Hearing Loss Nov 6, 2018
- Study points to possible new therapy for hearing loss Oct 15, 2018
- Cochlear neuron discovery could yield new treatments for hearing loss Sep 13, 2018
- Cochlear hair cell regeneration: an emerging opportunity to cure noise-induced sensorineural hearing loss May 4, 2018
Research
- Targeting the NLRP3 inflammasome in cochlear macrophages protects against hearing loss Sep 14, 2024
- A Selection Protocol to Identify Therapeutics to Target NLRP3-Associated Sensory Hearing Loss [MCC950] Sep 6, 2024
- A novel cell-free therapy using exosomes in the inner ear regeneration Apr 18, 2024
- Surface electrical stimulation of the auditory cortex preserves efferent medial olivocochlear neurons and reduces cochlear traits of age-related hearing loss Apr 12, 2024
- Unveiling the Role of Oxidative Stress in Cochlear Hair Cell Death: Prospective Phytochemical Therapeutics against Sensorineural Hearing Loss Apr 12, 2024
- Toward Optogenetic Hearing Restoration Apr 9, 2024
- A single dose of AC102 restores hearing in a guinea pig model of noise-induced hearing loss to almost prenoise levels Apr 1, 2024
- Potential role of modulating autophagy levels in sensorineural hearing loss Mar 10, 2024
- Lercanidipine’s Antioxidative Effect [Alleviates] Noise-Induced Hearing Loss Mar 7, 2024
- Use of CHEA to protect against age-related hearing loss: A proteomics study Feb 25, 2024
- AAV-mediated Gpm6b expression supports hair cell reprogramming Feb 24, 2024
- A novel pyridoindole (AC102) improves the recovery of residual hearing after a single application [Preprint] Feb 19, 2024
- Cochlear zinc signaling dysregulation is associated with noise-induced hearing loss, and zinc chelation enhances cochlear recovery Feb 14, 2024
- Current advances in biomaterials for inner ear cell regeneration Jan 12, 2024
- Development of Chinese herbal medicine for sensorineural hearing loss Nov 4, 2023
- Potential role of Bcl2 in lipid metabolism and synaptic dysfunction of age-related hearing loss Oct 7, 2023
- Intranasal delivery of NGF rescues hearing impairment in aged SAMP8 mice Sep 13, 2023
- Loss of synaptic ribbons is an early cause in ROS-induced acquired sensorineural hearing loss Sep 4, 2023
- Key genes and potential drugs in age-related hearing loss: transcriptome analysis of cochlear hair cells in old mice Aug 17, 2023
- Reversal of an existing hearing loss by gene activation in Spns2 mutant mice Aug 8, 2023
- Pharmaceutical characterization of probucol bile acid-lithocholic acid nanoparticles to prevent chronic hearing related and similar cellular oxidative stress pathologies Aug 2, 2023
- Space Station-like Composite Nanoparticles for Co-Delivery of Multiple Natural Compounds from Chinese Medicine and Hydrogen in Combating Sensorineural Hearing Loss Jul 28, 2023
- Altered Fhod3 Expression Involved in Progressive High-Frequency Hearing Loss via Dysregulation of Actin Polymerization Stoichiometry in The Cuticular Plate Jul 25, 2023
- Long-term NAD+ supplementation prevents the progression of age-related hearing loss in mice Jul 3, 2023
- In Silico Transcriptome-based Screens Identify Epidermal Growth Factor Receptor Inhibitors as Therapeutics for Noise-induced Hearing Loss [Preprint] Jun 9, 2023
- A prestin-targeting peptide-guided drug delivery system rearranging concentration gradient in the inner ear: an improved strategy against hearing loss Jun 7, 2023
- Mitochondrial alterations in the cochlea of Cdk5rap1-knockout mice with age-related hearing loss May 31, 2023
- Chromodomain helicase DNA binding protein 4 in cell fate decisions May 31, 2023
- Development and evaluation of helper dependent adenoviral vectors for inner ear gene delivery May 26, 2023
- The applications of Targeted Delivery for Gene Therapies in Hearing Loss May 22, 2023
- The applications of CRISPR/Cas-mediated genome editing in genetic hearing loss May 20, 2023
- Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels May 12, 2023
- Piceatannol protects against age-related hearing loss by inhibiting cellular pyroptosis and inflammation through regulated Caspase11-GSDMD pathway Apr 24, 2023
- Antioxidant Therapy as an Effective Strategy against Noise-Induced Hearing Loss: From Experimental Models to Clinic Apr 18, 2023
- Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell-like cells in adult mice Apr 17, 2023
- Enhanced survival of hypoimmunogenic otic progenitors following intracochlear xenotransplantation: repercussions for stem cell therapy in hearing loss models Apr 12, 2023
- Amelioration of Sensorineural Hearing Loss through Regulation of Trpv1, Cacna1h, and Ngf Gene Expression by a Combination of Cuscutae Semen and Rehmanniae Radix Preparata Apr 5, 2023
- Crossmodal plasticity in hearing loss Mar 27, 2023
- Valproic Acid Inhibits Progressive Hereditary Hearing Loss in a KCNQ4 Variant Model through HDAC1 Suppression Mar 17, 2023
- AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea Mar 14, 2023
- The NLRP3 inflammasome as a target for sensorineural hearing loss Mar 11, 2023
- Generation of p27icreER transgenic mice: A tool for inducible gene expression in supporting cells in the cochlea Mar 3, 2023
- The Dual Roles of Triiodothyronine in Regulating the Morphology of Hair Cells and Supporting Cells during Critical Periods of Mouse Cochlear Development Feb 27, 2023
- CRISPR-mediated RNA base editing: a promising strategy to rescue deafness Feb 27, 2023
- Potentials and limitations of pharmaceutical and pharmacological applications of bile acids in hearing loss treatment Feb 21, 2023
- Oridonin employs interleukin 1 receptor type 2 to treat noise-induced hearing loss by blocking inner ear inflammation Feb 16, 2023
- Promoting TFEB nuclear localization with curcumin analog C1 attenuates sensory hair cell injury and delays age-related hearing loss in C57BL/6 mice Feb 13, 2023
- Novel WFS1 mutations in patients with low-to-middle frequency hearing loss Feb 9, 2023
- Advances in gene therapy hold promise for treating hereditary hearing loss Feb 8, 2023
- The Expression and HC Regeneration Roles of the Super Elongation Complex in Mouse Cochlear Lgr5+ Progenitor Cells Oct 1, 2021
- VEGFR-MEK-TGFB1 signaling crosstalk as a potential target for hair cell regeneration and hearing restoration Sep 14, 2021
- miR-153 inhibition significantly restores KNCQ4 in cochlea after noise exposure, which attenuates sensorineural hearing loss Sep 3, 2021
- The expression of PHB2 in the cochlea: a new target for age-related hearing loss Aug 26, 2021
- Research Progress on the Mechanism of Cochlear Hair Cell Regeneration Aug 20, 2021
- Downregulation of Cav3.1 T-type Calcium Channel Expression in Age-related Hearing Loss Model Aug 17, 2021
- Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration Jul 30, 2021
- Local magnetic delivery of recombinant adeno-associated virus AAV2(quad Y-F) mediated brain-derived neurotrophic factor gene therapy restores hearing after noise injury Jul 20, 2021
- A Novel Small Molecule Neurotrophin-3 Analogue Promotes Inner Ear Neurite Outgrowth and Synaptogenesis In vitro Jul 15, 2021
- Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions Jul 7, 2021
- mTOR Signaling in the Inner Ear as Potential Target to Treat Hearing Loss Jun 14, 2021
- Roles of Key Ion Channels and Transport Proteins in Hearing Loss [Preprint] Jun 7, 2021
- Inhalation of Molecular Hydrogen, a Rescue Treatment for Noise-Induced Hearing Loss Jun 1, 2021
- Effects of Insulin-Like Growth Factor (IGF-1) in Patients with Sensorineural Hearing Loss May 31, 2021
- Advancements in Stem Cell Technology and Organoids for the Restoration of Sensorineural Hearing Loss May 25, 2021
- FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway May 19, 2021
- Neurog1, Neurod1, and Atoh1 are essential for spiral ganglia, cochlear nuclei, and cochlear hair cell development May 11, 2021
- Drug distribution along the cochlea is strongly enhanced by low-frequency round window micro vibrations [Preprint] May 6, 2021
- Primary Neural Degeneration in Noise-Exposed Human Cochleas: Implications for Regenerative Therapeutics Apr 21, 2021
- Nox3 might serve as a molecular target for the development of therapeutics for sensorineural hearing loss Apr 13, 2021
- Rapamycin Added to Diet in Late Mid-Life Delays Age-Related Hearing Loss in Mice Apr 7, 2021
- PBM/NAC treatment may reduce hair cell loss associated with noise-induced hearing loss Apr 6, 2021
- Protective Effects of N(1)-Methylnicotinamide (MNAM) Against Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein Apr 6, 2021
- Protective effects of vitamins/antioxidants on occupational noise-induced hearing loss: A systematic review Mar 31, 2021
- Transcription Factor Reprogramming in the Inner Ear: Turning on Cell Fate Switches to Regenerate Sensory Hair Cells Mar 29, 2021
- Congenital Deafness and Recent Advances Towards Restoring Hearing Loss Mar 29, 2021
- HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea Mar 25, 2021
- Oridonin ameliorates noise-induced hearing loss by blocking NLRP3 – NEK7 mediated inflammasome activation Mar 23, 2021
- Prevention of acquired sensorineural hearing loss by in vivo Htra2 gene editing Mar 22, 2021
- SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves Mar 22, 2021
- Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Plays a Protective Effect Against Noise-Induced Hearing Loss Mar 22, 2021
- Expression of serum proteins in noise induced hearing loss: insights into potential role in NIHL progression Mar 15, 2021
- The DNA methylation inhibitor RG108 protects against noise-induced hearing loss Mar 15, 2021
- Treatment With Calcineurin Inhibitor FK506 Attenuates Noise-Induced Hearing Loss Mar 12, 2021
- Hidden hearing loss is associated with loss of ribbon synapses of cochlea inner hair cells Mar 12, 2021
- Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss Mar 10, 2021
- ERBB2 is a Key Mediator in Hearing Restoration [Preprint] Mar 9, 2021
- VEGF-A165 gene therapy ameliorates blood-labyrinth barrier breakdown and hearing loss Mar 9, 2021
- Treatment of Long-term Sudden Sensorineural Hearing Loss as an Otologic Migraine Phenomenon Mar 5, 2021
- Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss Mar 2, 2021
- Molecular Behavior of HMGB1 in the Cochlea Following Noise Exposure and in vitro Feb 25, 2021
- Improved Speech Intelligibility in Subjects With Stable Sensorineural Hearing Loss Following Intratympanic Dosing of FX-322 in a Phase 1b Study Feb 22, 2021
- T2 relaxation time shortening in the cochlea of patients with sudden sensory neuronal hearing loss: changes in inner ear fluid composition implicated in idiopathic SSNHL development Feb 20, 2021
- Reduction of α2-Na/K-ATPase might play an important role in the pathogenesis of age-related hearing loss Feb 13, 2021
- An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure Feb 3, 2021
- ROS-Responsive Nanoparticle as a Berberine Carrier for OHC-Targeted Therapy of Noise-Induced Hearing Loss Feb 2, 2021
- A human induced pluripotent stem cell-based modular platform to challenge sensorineural hearing loss Jan 31, 2021
- Stem Cells and Gene Therapy in Progressive Hearing Loss: the State of the Art Jan 28, 2021
- Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells [Preprint] Jan 21, 2021
- Greater epithelial ridge cells display robust potential to generate inner ear organoids Jan 19, 2021
- Sudden Sensorineural Hearing Loss: A Diagnostic and Therapeutic Emergency Jan 15, 2021
Clinical Trials
- A Phase 1b/2a, Study Evaluating the Safety, PK/PD and Efficacy of NS101 in SSNHL Patients Feb 8, 2024
- Intra-Tympanic Steroid With PRP Combination in Sensorineural Hearing Loss and Tinnitus. Sep 6, 2023
- Assessment of The Efficacy of Intratympanic Platelet Rich Plasma for Treatment of Sensorineural Hearing Loss. Mar 27, 2023
- FX-322 in Adults With Acquired Sensorineural Hearing Loss Oct 20, 2021
- A Trial of LY3056480 in Patients With SNLH Sep 30, 2021
- FX-322 in Adults With Severe Sensorineural Hearing Loss Jul 6, 2021
- Phase I/IIa Study Evaluating Safety and Efficacy of an Intratympanic Dose of PIPE-505 in Subjects With Hearing Loss [Completed] Jun 24, 2021
- OTO-413 in Subjects With Speech-in-Noise Hearing Impairment Jun 18, 2021
- FX-322 in Sensorineural Hearing Loss [Completed] Mar 30, 2021
- Phase I/IIa Study Evaluating Safety and Efficacy of an Intratympanic Dose of PIPE-505 in Subjects With Hearing Loss Mar 3, 2021
- Verification of the Efficacy/Safety of the Dual Drug Delivery for Hearing Loss Mar 1, 2021
- FX-322 in Adults With Age-Related Sensorineural Hearing Loss Dec 16, 2020
- Efficacy of SENS-401 in Subjects With Severe or Profound Sudden Sensorineural Hearing Loss Nov 2, 2020
- FX-322 in Adults With Stable Sensorineural Hearing Loss Oct 8, 2020
- OTO-413 in Subjects With Speech-in-Noise Hearing Impairment Sep 14, 2020
- Protective Effects of EPI-743 on Noise-Induced Hearing Loss [Completed] Aug 31, 2020
- Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment [Terminated] Aug 7, 2020
- Phase 2a Study of FX-322 Administered by Intratympanic Injection in Adults With Stable Sensorineural Hearing Loss Apr 10, 2020
- High Dose Oral Steroids in Sudden Sensorineural Hearing Loss [Suspended] (On hold due to COVID-19 outbreak) Apr 8, 2020
- Safety and Efficacy of STR001-IT and STR001-ER in Patients With SSHL [Completed] Mar 25, 2020
- Safety, Tolerability and Efficacy for CGF166 in Patients With Unilateral or Bilateral Severe-to-profound Hearing Loss [Completed] Mar 18, 2020
- Intratympanic Steroids for Sudden Hearing Loss Oct 17, 2019
- Vestibular Prognosis Assessment of ISSNHL With Vestibular Dysfunction Treated With Oral or Intratympanic Glucocorticoids Jun 7, 2019
- Phase 3 Clinical Trial: D-methionine to Reduce Noise-Induced Hearing Loss (NIHL) [Terminated] Apr 29, 2019
- A Phase 2b Study of SPI-1005 to Prevent Acute Noise Induced Hearing Loss (PANIHL) Aug 24, 2018
Projects
- Hippo-mediated control of growth and regeneration in the inner ear sensory organs Feb 1, 2023
- Contribution of Macrophages and Fractalkine Towards Degeneration and Repair of Cochlear Synapses Mar 5, 2021
- The effects of cochlear pericytes and pericyte-related vascular pathology on hearing function Feb 14, 2020
- The Role of Notch Signaling in the Maintenance and Function of Cochlear Sensory Cells May 1, 2019